ATP-dependent mechanics of red blood cells

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ATP-dependent mechanics of red blood cells.

Red blood cells are amazingly deformable structures able to recover their initial shape even after large deformations as when passing through tight blood capillaries. The reason for this exceptional property is found in the composition of the membrane and the membrane-cytoskeleton interaction. We investigate the mechanics and the dynamics of RBCs by a unique noninvasive technique, using weak op...

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Dynamics of shear-induced ATP release from red blood cells.

Adenosine triphosphate (ATP) is a regulatory molecule for many cell functions, both for intracellular and, perhaps less well known, extracellular functions. An important example of the latter involves red blood cells (RBCs), which help regulate blood pressure by releasing ATP as a vasodilatory signaling molecule in response to the increased shear stress inside arterial constrictions. Although s...

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Mechanics of the red blood cell network

Changes in the microstruture of blood caused by the red blood cell aggregation phenomenon affect the mechanical properties of the fluid. This fact has been extensively investigated in the past and it has been verified that the formation of rouleaux (the characteristic coin-pile like structures) and aggregates at low shear rates affect the flow and as a consequence the viscosity of the fluid is ...

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Abstract Background and Objectives There is a circadian rhythm and diurnal variation in the redox capacity in blood plasma and there is a decrease in antioxidant capacity (TAC) during the RBCs storage in blood banking. So it is possible that donated blood, based on donation time, has a different antioxidant capacity and as a result a different biochemical response during storage. This study at...

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ژورنال

عنوان ژورنال: Proceedings of the National Academy of Sciences

سال: 2009

ISSN: 0027-8424,1091-6490

DOI: 10.1073/pnas.0904614106